Domain-immunoglobulin fusion proteins

Domain-immunoglobulin fusion proteins

  • CN 101,687,933 A
  • Filed: 05/30/2008
  • Published: 03/31/2010
  • Est. Priority Date: 05/30/2007
  • Status: Active Application
First Claim
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1. the polypeptide that is expressed from the next:

  • N′

    -(Z1) p-Y-Z2-Z3-Z4-C′

    Wherein N '"'"' is the N-end of described polypeptide and the C-end that C '"'"' is described polypeptide;

    Z1 is an aminoacid sequence, and it is included in (i) SEQ ID NO;

    11 or the (ii) end parts of C-at least of the amino-acid residue of 90 to 98 positions of SEQ ID NO;

    14;

    Y is an aminoacid sequence, and it is included in 99 to 113 positions of (i) SEQ ID NO;

    11 or the (ii) end parts of C-at least of the amino-acid residue of 99 to 162 positions of SEQID NO;

    14;

    Z2 is an aminoacid sequence, and it is included in 111 to 147 positions of (i) SEQ ID NO;

    12 or the (ii) end parts of N-at least of the amino-acid residue of 163 to 199 positions of SEQ ID NO;

    14;

    Z3-Z4 is selected from following aminoacid sequence;

    (i) by in the C-end parts of the amino-acid residue of 118 to 223 positions of SEQ ID NO;

    11 and the continuous amino acid sequence formed in the N-end parts of the amino-acid residue of 224 to 330 positions of SEQ ID NO;

    11, (ii) by in the C-end parts of the amino-acid residue of 114 to 219 positions of SEQ ID NO;

    12 and the continuous amino acid sequence formed in the N-end parts of the amino-acid residue of 220 to 326 positions of SEQ ID NO;

    12, (iii) by in the C-end parts of the amino-acid residue of 165 to 270 positions of SEQ ID NO;

    24 and the continuous amino acid sequence formed in the N-end parts of the amino-acid residue of 271 to 377 positions of SEQ ID NO;

    24, and (iv) by in the C-end parts of the amino-acid residue of 115 to 220 positions of SEQ IDNO;

    13 and the continuous amino acid sequence formed in the N-end parts of the amino-acid residue of 221 to 327 positions of SEQ ID NO;

    13;

    AndP is 0 or 1 integer,Wherein the amino-acid residue sum of Z2 and Z3 is between 80 to 140, and two ends numerical value is included;

    AndWherein the amino-acid residue sum of polypeptide is between 154 to 288, and two ends numerical value is included.

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