Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel

Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel

  • CN 101,704,804 A
  • Filed: 10/07/2005
  • Published: 05/12/2010
  • Est. Priority Date: 10/08/2004
  • Status: Active Application
First Claim
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1. 10-deacetylation-two-7;

  • the preparation method of 10-tribromo-acetyl base Baccatine III;

    determine at this 10-deacetylation-two-7 by HPLC;

    in the 10-tribromo-acetyl base Baccatine III corresponding 7 or the content of 10 list-tribromo-acetyl radical derivatives be lower than 0.1%, described preparation method comprises reaction mixture is carried out silica gel chromatography.

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