Method and device for optimizing and scaling up vitamin B12 fermentation process

Method and device for optimizing and scaling up vitamin B12 fermentation process

  • CN 101,775,424 A
  • Filed: 09/11/2008
  • Published: 07/14/2010
  • Est. Priority Date: 09/11/2008
  • Status: Active Application
First Claim
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1. one kind is optimized the method for amplification to the fermenting process that uses bioreactor device, it is characterized in that described method comprises step:

  • (a) physiological metabolism parameter, physiological metabolism parameter correlation characteristic or its combination in the described fermenting process of the described bioreactor device of mensuration;

    Wherein said physiological metabolism parameter is selected from;

    the meta-bolites of oxygen-supplying amount, dissolved oxygen, oxygen uptake rate, pH, carbonic acid gas release rate, respiratory quotient, amount of viable cell or cellular form, mensuration or substrate consumption or its combination;

    (b) physiological metabolism parameter, physiological metabolism parameter correlation characteristic or its combination of described physiological metabolism parameter, physiological metabolism parameter correlation characteristic and the preset value that step (a) is measured compare;

    Select the bioreactor device the most approaching with described preset value;

    Determine the amplification bioreactor device of optimization;

    Wherein said physiological metabolism parameter is as described in the step (a).

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