For transfection and the mixture for immunostimulating RNA and cationic peptide

For transfection and the mixture for immunostimulating RNA and cationic peptide

  • CN 101,796,191 B
  • Filed: 09/04/2008
  • Issued: 11/25/2015
  • Est. Priority Date: 09/04/2007
  • Status: Active Grant
First Claim
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1. in immune system, be used for the treatment of application to be activated the RNA of the compound of non-specific immune systems by activation mode identification receptor, it comprises the RNA molecule of at least one and one or more oligopeptides compounds, wherein nitrogen/phosphorus ratio, namely N/P-ratio is 0.75-25, and wherein said oligopeptides has 8-15 amino acid whose length and has following empirical formula:

  • (Arg) l;

    (Lys) m;

    (His) n;

    (Orn) o;

    (Xaa) xgeneral formula I Wherein●

    l+m+n+o+x=8-15, andL, m, n or o can be independently of one another be selected from 0,1,2,3,4,5,6,7,8,9,10,11,12,13,14 or 15 arbitrary numerical value, condition is that the total content of Arg, Lys, His and Orn represents this oligopeptides all amino acid whose at least 50%;

    With●

    Xaa is selected from the arbitrary amino acid in the natural or alpha-non-natural amino acid beyond Arg, Lys, His or Orn;

    With●

    X can be selected from 0,1,2,3,4,5,6,7 or 8 arbitrary numerical value, condition is that the total content of Xaa is no more than this oligopeptides all amino acid whose 50%,Wherein empirical formula (Arg) l;

    (Lys) m;

    (His) n;

    (Orn) o;

    (Xaa) xin Xaa be selected from the amino acid with neutral side chain, comprise the amino acid with neutral hydrophilic side chain and there is the amino acid of polar neutral side chain.

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