Nanoparticulate fibrate formulations

Nanoparticulate fibrate formulations

  • CN 101,797,233 A
  • Filed: 05/23/2003
  • Published: 08/11/2010
  • Est. Priority Date: 05/24/2002
  • Status: Active Application
First Claim
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1. special compositions of stable shellfish that is used for oral administration, it comprises:

  • (a) fenofibrate granule, wherein the particulate effective mean diameter of this fenofibrate is less than about 2000nm;

    With(b) with at least a surface stabilizer of the particulate surface-associated of fenofibrate, wherein;

    (i) described at least a surface stabilizer wherein surface stabilizer be selected from cetylpyridinium chloride, gelatin, casein, phospholipid, dextran, glycerol, Radix Acaciae senegalis, cholesterol, tragacanth, stearic acid, benzalkonium chloride, calcium stearate, glyceryl monostearate, cetostearyl alcohol, the cetomacrogol emulsifing wax, Isosorbide Dinitrate, polyoxyethylene alkyl ether, castor oil derivatives, polyoxyethylene sorbitan fatty acid ester, Polyethylene Glycol, bromination dodecyl trimethylammonium, Myrj 45, colloidal silica, phosphate, sodium lauryl sulphate, carboxymethylcellulose calcium, hydroxypropyl cellulose, hypromellose, sodium carboxymethyl cellulose, methylcellulose, hydroxyethyl-cellulose, Hydroxypropyl methyl cellulose phtalate, the amorphism cellulose, Magnesiumaluminumsilicate, triethanolamine, polyvinyl alcohol, polyvinylpyrrolidone, the 4-(1 that contains oxirane and formaldehyde, 1,3, the 3-tetramethyl butyl)-cascophen, poloxamer;

    Poloxamines, the different Nonylphenoxy of mixture, p-of dialkyl ester, sodium lauryl sulphate, alkyl aryl polyether sulfonate, sucrose stearate and the sucrose distearate of charged phospholipid, dioctyl sulfosuccinate, sodium sulfosuccinate gathers-((+)-2,3-Epoxy-1-propanol), caprinoyl-N-methyl glucamide;

    N-decyl β

    -D-glycopyranoside;

    N-decyl β

    -D-pyrans maltoside;

    N-dodecyl β

    -D-glycopyranoside;

    N-dodecyl β

    -D-maltoside;

    Oenanthyl-N-methyl glucamide;

    N-heptyl-β

    -D-glycopyranoside;

    N-heptyl β

    -D-sulfur glucosidase;

    N-hexyl β

    -D-glycopyranoside;

    Nonanoyl-N-methyl glucamide;

    N-noyl β

    -D-glycopyranoside;

    Decoyl-N-methyl glucamide;

    N-octyl group-β

    -D-glycopyranoside;

    Octyl group β

    -D-sulfur glycopyranoside;

    Lysozyme, PEG-phospholipid, the PEG-cholesterol, the PEG-cholesterol derivative, the PEG-vitamin A, the PEG-vitamin E, the random copolymer of vinylpyrrolidone and vinylacetate, bromination trimethylammonium polymethyl methacrylate, dimethyl sulfate polyvinylpyrrolidone-2-dimethyl aminoethyl methacrylate, cetab, cation lipid, sulfonium compound, phosphorus compound, quaternary ammonium compound, benzyl bromide-two (2-chloroethyl) ethyl ammonium, chlorination Oleum Cocois trimethylammonium, bromination Oleum Cocois trimethylammonium, chlorination Oleum Cocois methyl dihydroxy ethyl ammonium, bromination Oleum Cocois methyl dihydroxy ethyl ammonium, chlorination decyl three second ammoniums, the chlorination decyl dimethyl hydroxyethyl ammonium, chlorination or bromination decyl dimethyl hydroxyethyl ammonium, chlorination C 12-15Dimethyl hydroxyethyl ammonium, chlorination or bromination C 12-15Dimethyl hydroxyethyl ammonium, chlorination Oleum Cocois dimethyl hydroxyethyl ammonium, bromination Oleum Cocois dimethyl hydroxyethyl ammonium, myristyl trimethyl ammonium methylsulfuric acid ester, dodecyl dimethyl benzyl ammonium chloride, dodecyl dimethyl benzyl ammonium bromide, chlorination dodecyl dimethyl (oxygen ethylene) 4Ammonium, bromination dodecyl dimethyl (oxygen ethylene) 4Ammonium, chlorination N-alkyl (C 12-18) dimethyl benzyl ammonium, chlorination N-alkyl (C 14-18) dimethyl-hexadecyldimethyl benzyl ammonium, chlorination N-myristyl dimethyl benzyl ammonium monohydrate, chlorination dimethyl didecyl ammonium, chlorination N-alkyl and (C 12-14) dimethyl 1-naphthyl methyl ammonium, trimethylammonium halogenide, alkyl-front three ammonium salt, dialkyl group-diformazan ammonium salt, chlorination dodecyl trimethyl ammonium, ethoxylation alkyl amido alkyl dialkyl ammonium salt, ethoxylation trialkyl ammonium salts, chlorination dialkyl benzene dialkyl ammonium, chlorination N-didecyldimethyl ammonium, chlorination N-myristyl dimethyl benzyl ammonium monohydrate, chlorination N-alkyl (C 12-14) dimethyl 1-naphthyl methyl ammonium, dodecyl dimethyl benzyl ammonium chloride, chlorination dialkyl benzene alkylammonium, chlorination dodecyl trimethyl ammonium, chlorination alkyl benzyl ammonium methyl, bromination alkyl benzyl dimethyl ammonium, bromination C 12Trimethyl ammonium, bromination C 15Trimethyl ammonium, bromination C 17Trimethyl ammonium, chlorination dodecylbenzyl triethyl ammonium, chlorination be poly--diallyl dimethyl ammonium (DADMAC), dimethylammonium chloride, alkyl dimethyl ammonium halogenide, chlorination hexatriacontane ylmethyl ammonium, bromination decyl trimethyl ammonium, bromination dodecyl triethyl ammonium, Cetrimide, methyl tricaprylammonium chloride, POLYQUAT 10 TM, Tetrabutylammonium bromide, bromination benzyltrimethylammon.um, cholinester, benzalkonium chloride, stearyl dixylyl ammonium chloride compound, brocide, cetylpyridinium chloride, quaternized polyoxy ethyl alkylamine halogen, MIRAPOL TM, ALKAQUAT TM, Fixanol;

    Amine, amine salt, amine oxide, imino group azolinium salt, protonated quaternary ammonium acrylamide, quaternary ammonium polymer and cationic guar gum methylate;

    With The not phosphorous matter of (ii) described compositions.

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