Ph-dependent controlled release pharmaceutical composition for non-opioids with resistance against the influence of ethano

Ph-dependent controlled release pharmaceutical composition for non-opioids with resistance against the influence of ethano

  • CN 101,801,356 A
  • Filed: 09/25/2007
  • Published: 08/11/2010
  • Est. Priority Date: 09/21/2007
  • Status: Active Grant
First Claim
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1. pH the pharmaceutical composition of dependent controlled release comprises:

  • Examine core, comprise the active constituents of medicine of at least a eliminating opiates, its center core is controlled the coatings coating of the release of pharmaceutical composition by at least one,Wherein coatings comprises the polymeric blends of following material;

    I) with the dry weight basis of polymeric blends, at least a water-insoluble, the neutral in fact polyvinyl of 40-95 weight or copolymer andIi) with the dry weight basis of polymeric blends, at least a anionic polymer or the copolymer of 5-60 weight %, it is being lower than the insoluble and solvable in the scope of pH 8.0 at pH 7.0 at least in buffered medium of pH 4.0,Be characterised in that,With the dry weight basis of polymeric blends, this coatings contains the non-porous inert lubricant of 110-250 weight % and coatings in addition and exists with the amount of at least 60 weight % of nuclear core weight.

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