The pharmaceutical composition of the dependent controlled release of pH of the non-opium of ethanol tolerant impact

The pharmaceutical composition of the dependent controlled release of pH of the non-opium of ethanol tolerant impact

  • CN 101,801,356 B
  • Filed: 09/25/2007
  • Issued: 10/19/2016
  • Est. Priority Date: 09/21/2007
  • Status: Active Grant
First Claim
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1. The pharmaceutical composition of the dependent controlled release of 1.pH, comprises:

  • Nuclear core, comprises at least one active constituents of medicine getting rid of opiates, and wherein nuclear core is controlled drug regimen by least oneThe coatings coating of the release of thing,Wherein coatings includes the polymeric blends of following material;

    I) in terms of the dry weight of polymeric blends, at least one water-insoluble, substantially neutral ethylene of 40-95 weight %Based polyalcohol, described polyvinyl is selected from the polymer of polyvinyl acetate type, or (methyl) acrylic acid series copolymer;

    WithIi) in terms of the dry weight of polymeric blends, at least one anionic polymer of 5-60 weight %, it is less than pH 4.0Buffered medium in insoluble and at least solvable in the range of pH 7.0 to pH 8.0,It is characterised by,In terms of the dry weight of polymeric blends, this coatings additionally contains the non-porous inert lubricant of 110-250 weight % alsoAnd coatings exists with the amount of at least 60 weight % of nuclear core weight.

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