Preparation method of sodium tanshinone IIA for injection

Preparation method of sodium tanshinone IIA for injection

  • CN 101,805,391 B
  • Filed: 04/09/2010
  • Issued: 12/03/2014
  • Est. Priority Date: 04/09/2010
  • Status: Active Grant
First Claim
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1. a preparation method for sodium tanshinone IIA for injection, is characterized in that, comprises the following steps:

  • A) by 10~

    90% (v/v) dissolve with ethanol solution for Tanshinone II A sodium sulfonate crude product, temperature is 50 DEG C~

    65 DEG C;

    B) add sorbent material, temperature is 50 DEG C~

    65 DEG C, is uniformly mixed, while hot suction filtration;

    C) by step B) to filter the filtrate of gained and put the freezing crystallization of refrigeration chamber, recrystallization temperature be-4 DEG C~

    10 DEG C, and the time is 2~

    10 hours, and suction filtration is to doing;

    D) by step C) filter the filter cake of gained and put in 40~

    45 DEG C of drying under reduced pressure casees vacuum-drying 3~

    7 hours, to obtain final product.

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