A kind of Chinese medicine composition promotes the application in nitric oxide generating medicine in preparation

A kind of Chinese medicine composition promotes the application in nitric oxide generating medicine in preparation

  • CN 101,829,203 B
  • Filed: 03/11/2009
  • Issued: 08/19/2015
  • Est. Priority Date: 03/11/2009
  • Status: Active Grant
First Claim
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1. a Traditional Chinese medicine composition and N-nitro-L-arginine are preparing in myocardial ischemia-reperfusion the application raised in left ventricular end diastolic presssure medicine;

  • The ratio of described Chinese medicine composition and N-nitro-L-arginine is 0.4g;

    10mg;

    Described N-nitro-L-arginine uses with injection form;

    Described Chinese medicine composition is made up of following steps;

    A) crude drug formula is;

    Radix Ginseng 39.6g, Hirudo 72.6g, Eupolyphaga Seu Steleophaga 46.2g, Olibanum (processed) 13.2g, Radix Paeoniae Rubra 33g, Lignum Dalbergiae Odoriferae 13.2g, Lignum Santali Albi 13.2g, Scorpio 19.8g, Periostracum Cicadae 46.2g, Scolopendra 6.6g, Borneolum Syntheticum 33g, Semen Ziziphi Spinosae (parched) 33g;

    B) pulverizing medicinal materials technique;

    by Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and Periostracum Cicadae five kinds of worm medicines after cleaning, washing process and clean the Olibanum (processed) after the process of preparing Chinese medicine and prepare burden by prescription, pulverized by pulverizer, medicated powder fineness reaches more than 80 orders;

    Medicated powder after coarse powder carries out micronizing through various superfine communication technique, makes medicated powder mean diameter be less than 30-40 μ

    m;

    Medical material to be comminuted, after cleaning, drying sterilizing, is prepared burden;

    C) concentrated and drying process is extracted;

    use water extraction again after Lignum Dalbergiae Odoriferae and the first extracting in water volatile oil of Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, each 3 hours, merge Aqueous extracts, after filtration, one-tenth extractum to be concentrated;

    Radix Ginseng with appropriate 70% ethanol extraction secondary, each 3 hours, merge extractive liquid, reclaim ethanol extremely without alcohol taste, use water extraction again, it is 0.9 ~ 1.1 alcohol-extracted extract that alcohol extract is condensed into 60 DEG C of mensuration relative densities, and Aqueous extracts is concentrated into 60 DEG C after filtering and mixing with above-mentioned all Aqueous extracts and measures the clear paste that relative density is 0.9 ~ 1.1, for subsequent use;

    D) preparation process;

    add superfine powder flour in Fluidbedgranulatingdrier, then by step c) gained extracts extractum and sprays into granulation;

    By the granule made through granulate, add Borneolum Syntheticum fine powder, spray into the volatile oil extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by capsule filler filling after mixing, make 1000 capsules.

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