Method for the nano particle that the gem-diphosphonate stabilized zone of preparation with hydrophilic biodistribution ligand coupling covers

Method for the nano particle that the gem-diphosphonate stabilized zone of preparation with hydrophilic biodistribution ligand coupling covers

  • CN 101,835,498 B
  • Filed: 10/06/2008
  • Issued: 08/24/2016
  • Est. Priority Date: 10/05/2007
  • Status: Active Grant
First Claim
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1. , for preparing a kind of method of metal nanoparticle, these metal nanoparticles include the gold covered by organic stabilizers layerBelong to core N, this organic stabilizers layer and at least one metal Ion-hydrophilic Ligand coupling, the stability/life to these nano particles of this metal Ion-hydrophilic LigandThing credit cloth has impact, and the method comprises the following steps:

  • A) the metal-cored N of these metal nanoparticles is prepared;

    B) preparation has the targeting key element of chemical formula S-C, wherein;

    -S is to have chemical formula X-L-CH (PO3H2)2Gem-diphosphonate attachment group;

    -C is hydrophilic biodistribution part, and it is the compound of following formula;

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