For the immunoassay quantitative to the labile antigen selected from BNP and proBNP

For the immunoassay quantitative to the labile antigen selected from BNP and proBNP

  • CN 101,842,707 B
  • Filed: 04/14/2008
  • Issued: 11/09/2016
  • Est. Priority Date: 04/13/2007
  • Status: Active Grant
First Claim
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1. purposes in manufacturing kit for the SA, wherein said kit is used for detecting in sampleThe labile antigen being selected from the group:

  • BNP, proBNP and comprising11FGRKMDRISSSS22Fragment,Described method includesA () makes the fragment to BNP molecule for the described antigen contact11FGRKMDRISSSS22(SEQ IDNO;

    3) specific first antibody, to obtain one-level immune complex;

    B () makes the described SA of described one-level immune complex contact that step (a) obtains, to obtain twoLevel immune complex;

    AndC () is detected described secondary immune compound and is formed,One-level immune complex described in wherein said SA identification, and can not identify free BNP,ProBNP or its comprise11FGRKMDRISSSS22Fragment or free first antibody, or with than it knowThe affinity identification of low 10 times or less of not described one-level immune complex they.

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