Modified small interfering RNA and preparation method thereof

Modified small interfering RNA and preparation method thereof

  • CN 101,851,618 A
  • Filed: 04/03/2009
  • Published: 10/06/2010
  • Est. Priority Date: 04/03/2009
  • Status: Active Application
First Claim
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1. the small RNA of a modification, it comprises first fragment and second fragment, and described first fragment and second fragment can form double-stranded region, described first fragment comprises at least one successive UA sequence, described second fragment comprises at least one and the described first segmental UA sequence complementary successive UA sequence, the described first segmental UA sequence and the described second segmental UA sequence form the UA/UA site, it is characterized in that, at least one Nucleotide in the described UA/UA site is through modifying, and this modification makes the stability of the small RNA of modification be higher than the small RNA of unmodified.

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