For the drug delivery system of prevention of cerebral vasospasm

For the drug delivery system of prevention of cerebral vasospasm

  • CN 101,873,858 B
  • Filed: 06/11/2008
  • Issued: 05/25/2016
  • Est. Priority Date: 06/11/2007
  • Status: Active Grant
First Claim
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1. a particle medicinal composition has a cerebral angiospasm risk for the preparation for the treatment of human objectArteriocerebral sustained release delivery system in purposes, described treatment comprises the following steps:

  • A) provide the therapeutic agent that contains therapeutic dose and the described pharmaceutical composition of carrier, wherein, described therapeutic agentContain L-type valtage-gated calcium channel inhibitor, and described carrier contains multiple particulates, wherein, described L-Type valtage-gated calcium channel inhibitor is dispersed in each particulate;

    AndB) in cavum subarachnoidale by injection site give pharmaceutical composition described in described human object, instituteStating composition is characterised in that;

    (i) the described therapeutic agent of described therapeutic dose disperses in each particulate;

    (ii), as dispersion liquid, after local delivery, it is at the described spider web of the described brain with vasopasm riskDescribed cerebral artery mobility around in hypostegal cavity;

    (iii) within the time period extending, described therapeutic agent progressively discharges from described composition;

    With(iv) not to cause the amount of unnecessary side effect to enter the local pharmacological action of body circulation.

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