Be used to prevent and treat associated conditions and as the diaryl and the aryl heteroaryl urea derivatives of 5-HT2A serotonin receptor modulator

Be used to prevent and treat associated conditions and as the diaryl and the aryl heteroaryl urea derivatives of 5-HT2A serotonin receptor modulator

  • CN 101,875,961 A
  • Filed: 07/21/2004
  • Published: 11/03/2010
  • Est. Priority Date: 07/22/2003
  • Status: Active Application
First Claim
Patent Images

1. the 5-HT of an external definite test compounds 2AThe active method of inverse agonist, it comprises:

  • A. the human 5-HT of composition activatory that in a plurality of cell cultures hole, provide transfection 2AThe host cell of receptor cdna;

    B. in each described hole, add test compounds;

    WithC. by measuring IP 3Accumulate and the 5-HT of definite described test compounds 2AThe inverse agonist activity;

    Wherein, 1-[3-(4-bromo-2-methyl-2H-pyrazole-3-yl)-4-methoxyl group-phenyl]-(2,4-two fluoro-phenyl)-urea is one of described test compounds to 3-.

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