New BNP(1-32) epitope and antibodies directed against said epitope

New BNP(1-32) epitope and antibodies directed against said epitope

  • CN 101,878,225 B
  • Filed: 08/01/2008
  • Issued: 05/24/2017
  • Est. Priority Date: 08/03/2007
  • Status: Active Grant
First Claim
Patent Images

1. the polypeptide of carrier BNP (1-32) epitope, it has formula (I):

  • a1-R1-X1-FGRKMDR-X2-R2-a2 (I)Wherein-a1It is that H or expression are selected from following functional group or chemical group:

    Mercaptan, alcohol, aminooxy group, primary amine or secondary amine functional groups,Aminocarboxylic group, biotinyl groups and Acetyl Groups;

    -a2Represent OH, NH2Functional group or alkoxy base;

    -X1In the absence of or exist, and when it is present, it is selected from C and GC;

    -X2In the absence of or exist, and when it is present, it is selected from I and IS;

    -R1And R2, be it is identical or different, it is presence or absence of, and its represent any amino acid or 2 to 15 aminoAcid peptide chain, condition be formula (I) the polypeptide include containing sequence GCFGRKMDRIS more than 11 people of amino acidAny part of BNP (1-32),Wherein described polypeptide is selected from sequence SEQ ID NO:

    4、

    a1-SGCFGRKMDR-a2

    a1-GCFGRKMDRI-a2

    a1-CFGRKMDRIS-a2And a1-FGRKMDRISS-a2, wherein a1And a2It is as defined above,Or the polypeptide corresponds to formula (II):

    a1-FGRKMDR-a2 (II)Wherein a1And a2It is as defined above.

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