Methods and compositions for inactivating alpha-1,6 fucosyltransferase (FUT 8) gene expression

Methods and compositions for inactivating alpha-1,6 fucosyltransferase (FUT 8) gene expression

  • CN 101,883,850 A
  • Filed: 07/10/2008
  • Published: 11/10/2010
  • Est. Priority Date: 07/12/2007
  • Status: Active Application
First Claim
Patent Images

1. it is that 4 kinds of zinc of F1 to F4 refer to cog region that zinc finger dna binding domains, wherein said DNA binding domains comprise from N-terminal to C-terminal order, and wherein F1, F2, F3 and F4 comprise following aminoacid sequence:

  • F1:

    QSSDLSR(SEQ?ID?NO:

    9);

    F2:

    TSGNLTR(SEQ?ID?NO:

    10);

    F3;

    RSDDLSK (SEQ ID NO;

    11);

    WithF4:

    DRSALAR(SEQ?ID?NO:

    12)。

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