Use the microparticle multiplex detection method to detect the method for dysploidy

Use the microparticle multiplex detection method to detect the method for dysploidy

  • CN 101,956,002 A
  • Filed: 07/02/2004
  • Published: 01/26/2011
  • Est. Priority Date: 07/04/2003
  • Status: Active Application
First Claim
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1. following three kinds of materials are used for purposes in the diagnostic reagent that one or more karyomit(e)s the experimenter detect dysploidy simultaneously in preparation:

  • (i) the polynucleotide sample of fluorescence mark, the representative of each karyomit(e) abundance that described polynucleotide sample is described experimenter;

    (ii), use the fluorescent mark substance markers different with sample at each chromosomal non--dysploidy polynucleotide standard that is equal to;

    With(iii) at each chromosomal limited amount wedding agent, it is used for mixing with described sample and described standard, wherein said wedding agent comprise with at each chromosomal sample and standard complementary polynucleotide, it is fixed on the microparticle kind, and at different aspect the microparticle number of each chromosomal each class microparticle in fluorescent marker and this microparticle kind;

    Fluorescent marker on the wherein said microparticle if any, has the emmission spectrum different with the marker of sample and standard;

    Wherein said diagnostic reagent detects dysploidy by described sample and described standard with aniso-combination of described wedding agent.

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