The production method of 5'-GMP

The production method of 5'-GMP

  • CN 101,960,005 B
  • Filed: 02/25/2009
  • Issued: 02/24/2016
  • Est. Priority Date: 02/25/2008
  • Status: Active Grant
First Claim
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1. produce a method for 5'"'"'-GMP, the method comprises:

  • In reaction solution, making t-inosinic acid carry out reacting thus generating 5'"'"'-GMP with the microorganism with ability t-inosinic acid being converted into 5'"'"'-GMP, wherein carrying out the microorganism cells perviousness of activated oligonucleotide by adding organic solvent in reaction solution, andCollect 5'"'"'-GMP,Wherein said microorganism enhances imp dehydrogenase activity and 5'"'"'-GMP synthase activity through modifying, wherein said microorganism also makes through modifying1) ushA gene and aphA gene are destroyed,2) one or more genes be selected from purR gene, add gene and purA gene are destroyed, and3) nagD gene is destroyed, and wherein said microorganism is intestinal bacteria.

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