1,25-dihydroxyvitamin D 2 and its preparation method of stabilization

1,25-dihydroxyvitamin D 2 and its preparation method of stabilization

  • CN 101,998,949 B
  • Filed: 03/12/2009
  • Issued: 11/25/2015
  • Est. Priority Date: 03/12/2008
  • Status: Active Grant
First Claim
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1. purification of crude 1, a 25-dihydroxyvitamin D 2method, comprise I () is by solvent system crystallization 1, the 25-dihydroxyvitamin D not containing methyl-formiate 2, described solvent system is the mixture of acetone/water;

  • (ii) solvent system is used to wash 1,25-dihydroxyvitamin D of described crystallization 2, described solvent system is the mixture of acetone/water;

    With (iii) 1,25-dihydroxyvitamin D of dry described crystallization 2to remove residual solvent, Wherein 1,25-dihydroxyvitamin D of gained purifying 2the feature of composition is A () does not contain methyl-formiate, andB the amount of () wherein total residual solvent is 1.0% or lower.

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