Compositions and methods for inhibiting expression of Eg5 and VEGF genes

Compositions and methods for inhibiting expression of Eg5 and VEGF genes

  • CN 102,014,932 A
  • Filed: 03/05/2009
  • Published: 04/13/2011
  • Est. Priority Date: 03/05/2008
  • Status: Active Application
First Claim
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1. one kind comprises first double stranded RNA (dsRNA) that suppresses human kinesin family member 11 (Eg5/KSP) expression of gene in the cell and the compositions that suppresses the 2nd dsRNA of the expression of people VEGF in the cell, and wherein:

  • a described dsRNA and described the 2nd dsRNA are mixed with stable nucleic acid lipid particles (SNALP);

    A described dsRNA is made up of first positive-sense strand and first antisense strand, and described first positive-sense strand comprises that first sequence and described first antisense strand comprise complementary second sequence of at least 15 continuous nucleotides with SEQ ID NO;

    1311 (5 '"'"'-UCGAGAAUCUAAACUAACU-3 '"'"'), wherein said first sequence and the described second sequence complementation and a wherein said dsRNA are 15 to 30 base pairs on length;

    Form by second positive-sense strand and second antisense strand with described the 2nd dsRNA, described second positive-sense strand comprises that the 3rd sequence and described second antisense strand have complementary the 4th sequence of at least 15 continuous nucleotides with SEQ ID NO;

    1538 (5 '"'"'-GCACAUAGGAGAGAUGAGCUU-3 '"'"'), wherein said the 3rd sequence and described the 4th sequence complementation and wherein each chain be 15 to 30 base pairs on length.

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