Method for crystallization of 2-amino-2-[2-[4-(3- benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride

Method for crystallization of 2-amino-2-[2-[4-(3- benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride

  • CN 102,046,594 A
  • Filed: 03/18/2009
  • Published: 05/04/2011
  • Est. Priority Date: 03/24/2008
  • Status: Active Application
First Claim
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1. crystallization method, it is 2-amino-2-[2-[4-(3-benzyloxy thiophenyl)-2-chloro-phenyl-] ethyl]-1, the crystallization method of ammediol hydrochloride is characterized in that, has:

  • (1) with 2-amino-2-[2-[4-(3-benzyloxy thiophenyl)-2-chloro-phenyl-] ethyl]-1, ammediol is dissolved in its hydrochloride solubleness high solvent and the mixed solvent to the low solvent of its hydrochloride solubleness, with preparation 2-amino-2-[2-[4-(3-benzyloxy thiophenyl)-2-chloro-phenyl-] ethyl]-1, the operation of the solution of ammediol, then(2) under agitation, in above-mentioned solution, add hydrochloric acid so that 2-amino-2-[2-[4-(3-benzyloxy thiophenyl)-2-chloro-phenyl-] ethyl]-1, the hydrochloride of ammediol carries out the operation of crystallization.

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