The immediate release formulation of the enhancing of Topiramate

The immediate release formulation of the enhancing of Topiramate

  • CN 102,114,002 B
  • Filed: 12/04/2007
  • Issued: 05/11/2016
  • Est. Priority Date: 12/04/2006
  • Status: Active Grant
First Claim
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1. for the preparation of the Topiramate to mammalian subject oral administration, it comprises:

  • (a) composition discharging immediately of the enhancing that contains Topiramate, it comprises complexing agent, reinforcing agent or their combination, the composition discharging immediately wherein strengthening described at least a portion is included at least one group of globule, wherein said globule comprises inert carrier and contains the Topiramate being coated on described carrier, and wherein Topiramate stripping within the time period that is no more than 1 hour of at least 80%;

    With(b) composition that the prolongation that contains Topiramate discharges,Wherein, described preparation is comprised in capsule, and the particle diameter of described Topiramate is 2 μ

    m-200 μ

    m,Wherein, described complexing agent is selected from cyclodextrin, described reinforcing agent is selected from VE TPGS, glutamic acid, glycine, D-sorbite, mannose, maltose, sweet mellow wine, lactose, glucose, xylitol, dextrin, glycerine-polyethylene glycol oxygen base stearate, PEG-32 glyceryl palmitostearate, lauryl sodium sulfate, polyoxyethylene list oleic acid sorbitan ester, phenmethylol, mono laurate sorbitan ester, poloxamer188, polyethylene glycol, polyvinylpyrrolidone, polyalcohol, polyvinyl alcohol, oleic acid, glycerin mono-fatty acid ester, Sodium Benzoate, cetanol, sucrose stearate, Crospovidone, sodium starch glycolate, cross-linked carboxymethyl cellulose sodium, carboxymethyl cellulose, starch, HPMC, the hydroxypropyl cellulose replacing, microcrystalline cellulose, sodium acid carbonate, calcium citrate, docusate sodium, and menthol.

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