Cationized mulberry polysaccharide nanoparticle gene vectors and manufacturing method thereof

Cationized mulberry polysaccharide nanoparticle gene vectors and manufacturing method thereof

  • CN 102,154,349 B
  • Filed: 12/30/2010
  • Issued: 08/06/2014
  • Est. Priority Date: 12/30/2010
  • Status: Active Grant
First Claim
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1. a polysaccharides of Folium Mori nanoparticle genophore for cationization, is characterized in that:

  • it is the genophore of a kind of polysaccharides of Folium Mori of modifying with aminated compounds in conjunction with DNA plasmid, and the molecular weight distribution of polysaccharides of Folium Mori is 3~

    3.5 ×

    10 4da, wherein counts the polysaccharides of Folium Mori of cationization;

    DNA plasmid=0.5~

    100 in mass ratio;

    1, the particle diameter of plasmid is 50-150nm, described aminated compounds is that spermine, quadrol or number-average molecular weight are the polymine of 600Da-2000Da.

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