Non-viral compositions and methods for transfecting gut cells in vivo

Non-viral compositions and methods for transfecting gut cells in vivo

  • CN 102,164,618 A
  • Filed: 03/30/2007
  • Published: 08/24/2011
  • Est. Priority Date: 03/30/2006
  • Status: Active Application
First Claim
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1. comprise compositions based on the nanoparticle of chitosan, described nano-particle based on chitosan comprises a plurality of chitosan polymers and the (ii) therapeutic construct that (i) has the mean molecule quantity of 3kDa to 250kDa, wherein said therapeutic construct comprises can be operationally connected to the therapeutic nucleic acids that the expression regulation of function district is arranged in intestinal mucosa cells, can bring into play therapeutical effect when wherein said therapeutic nucleic acids is expressed in described intestinal mucosa cells, and wherein said nanoparticle based on chitosan can cause the expression that described therapeutic nucleic acids was longer than at intestinal mucosa 4 days.

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