Medicinal transparent nano dispersant and preparation method thereof

Medicinal transparent nano dispersant and preparation method thereof

  • CN 102,188,372 B
  • Filed: 03/12/2010
  • Issued: 12/03/2014
  • Est. Priority Date: 03/12/2010
  • Status: Active Grant
First Claim
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1. a preparation method for medicinal transparent nano dispersant, is characterized in that, this dispersion is to take the colloidal dispersion system that shipwreck soluble drug nano-particle is stabilizing agent as active component, water as disperse medium, pharmaceutic adjuvant, and concrete step and method is as follows:

  • A;

    crude drug is dissolved in the organic solvent that can dissolve each other with water, removes impurity through filtering with microporous membrane, being configured to concentration is 10-50mg/mL clarification drug solution;

    B;

    pharmaceutic adjuvant is soluble in water, and being made into concentration is the adjuvant aqueous solution of 1.2525-50mg/mL,, and control aqueous temperature at 3-30 ℃

    ;

    C;

    the pharmaceutic adjuvant aqueous solution of the drug solution of A step and B step while are stirred, obtain Nano medication slurry, wherein the volume ratio of drug solution and aqueous solution is 1;

    5-40;

    D;

    the nano pulp spraying of C step is dry, obtain spray powder, the dry time control inlet temperature processed of spraying is 100-180 ℃

    , and outlet temperature is 60-95 ℃

    , and charging rate is 5-40mL/min, and compressed air pressure is 0.4-0.8Mpa;

    E;

    the spray powder of D step is placed in to water, after water soluble adjuvant dissolves, can obtains medicinal transparent nano dispersant;

    Above-mentioned raw materials medicine is silibinin, irbesartan or itraconazole;

    Described organic solvent is methanol, ethanol, acetone, propanol, isopropyl alcohol, glycerol, n-butyl alcohol, oxolane, N, one or more mixture in dinethylformamide, dimethyl sulfoxide, stabilizing agent described above is polymer and ionic surfactant, the mass ratio of ionic surfactant and polymer is 0.2-100%, wherein, polymer is one or more the mixture in Polyethylene Glycol, polyvinylpyrrolidone, polyacrylamide, hydroxypropyl emthylcellulose, lactose;

    Ionic surfactant is a kind of in potassium stearate, sodium stearate, enuatrol, sodium lauryl sulphate, dodecylbenzene sodium sulfonate, Stepanol MG or their mixture;

    The mass ratio of stabilizing agent and medicine is 60-500;

    100.

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