There is the medicine of the PK (pharmacokinetic) profile of improvement

There is the medicine of the PK (pharmacokinetic) profile of improvement

  • CN 102,198,140 B
  • Filed: 02/16/2006
  • Issued: 06/08/2016
  • Est. Priority Date: 03/01/2005
  • Status: Active Grant
First Claim
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1. a pharmaceutical preparation, it is fast disintegration in the oral cavity, and containing with Vardenafil calculate 0.8% to 25% and the Vardenafil of salt form that acid is formed or Vardenafil and acid and 40% to 99%, be selected from N.F,USP MANNITOL or sorbyl alcohol, Pharmaburst?Or Pharmaburst?The sugar alcohol of B2, it is characterized in that:

  • the Vardenafil dosage of at least 80% is dissolved in 10 ml physiological salines in 25 DEG C from material form used, described pharmaceutical preparation in USP blade whipping device with when every minute stirring velocity of 50 turns and 37 DEG C in 900 ml physiological salines the release rate in first 5 minutes be at least 70%, it is further characterized in that, disintegration time was less than 3 minutes, and effective constituent is mixed mutually with sugar alcohol and other auxiliary material, and finally described mixture is suppressed on tabletting machine.

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