Ebastine solid dispersion and Ebastine tablets prepared therefrom

Ebastine solid dispersion and Ebastine tablets prepared therefrom

  • CN 102,218,041 B
  • Filed: 04/15/2010
  • Issued: 08/05/2015
  • Est. Priority Date: 04/15/2010
  • Status: Active Grant
First Claim
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1. an ebastine solid dispersion, is characterized in that, it comprises ebastine, poloxamer F68 and PVP K30;

  • Described ebastine solid dispersion is prepared by following method;

    get ebastine, poloxamer F68 and PVP K30, add medicinal alcohol, stir, heating, makes abundant mixing, continue to stir, pressure reducing and steaming solvent, is chilled to room temperature, filters, vacuum drying, obtains described ebastine solid dispersion;

    Wherein, ebastine 5.7 parts, poloxamer F6822.8 part and PVP K30 11.4 parts is contained in described ebastine solid dispersion;

    Or containing ebastine 5.7 parts, poloxamer F6811.4 part and PVP K30 5.7 parts;

    Wherein heating-up temperature is 40-60 DEG C, and continuation mixing time is 0.5-2 hour, and the temperature of pressure reducing and steaming solvent is 45-65 DEG C, and vacuum drying temperature is 50-70 DEG C.

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