Gene therapy vector and cytosine deaminase

Gene therapy vector and cytosine deaminase

  • CN 102,227,501 B
  • Filed: 09/26/2009
  • Issued: 11/16/2016
  • Est. Priority Date: 09/26/2008
  • Status: Active Grant
First Claim
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1. the carcinogenic retrovirus vector of replication competent type mammal of restructuring, it comprises the polynucleotide of separation, this separationPolynucleotide are inserted in pAC3, and wherein the polynucleotide of this separation comprise:

  • The polypeptide of coding SEQ ID NO;

    4, SEQ ID NO;

    19 that people is codon optimized are from nucleotides number 8877 to 9353The polynucleotide of sequence, wherein said polypeptide has cytosine deaminase (CD) activity.

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