The production of influenza vaccines

The production of influenza vaccines

  • CN 102,257,135 B
  • Filed: 12/16/2009
  • Issued: 06/09/2017
  • Est. Priority Date: 12/16/2008
  • Status: Active Grant
First Claim
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1. , comprising the vaccine for resetting influenza A virus, the virus is included:

  • I () encodes the polynucleotides of PB1, coding PA'"'"'s is moreNucleotides, encodes the polynucleotides of PB2, encodes the polynucleotides of M, encodes the polynucleotides of NP, encodes the polynucleotides of NS, interiorThe polynucleotides of portion gene PB1, PA, PB2, M, NP and NS are derived from the first H5N1 influenza virus, and (ii) coded surfaceThe polynucleotides of albumen HA and the polynucleotides of coded surface albumen NA, each in HA and NA come from second H5N1 influenzaVirus,The polynucleotides are operably connected, to allow the polynucleotides reset to be packaged in virion, wherein the HAGene is by from RERRRKKR (SEQ ID NO;

    13)→

    TETR(SEQ ID NO;

    14) mutation is in many alkalescence cleavage site quiltsModify to produce attenuated virus.

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