Method for the synthesis of phosphorus atom modified nucleic acids

Method for the synthesis of phosphorus atom modified nucleic acids

  • CN 102,282,155 A
  • Filed: 12/02/2009
  • Published: 12/14/2011
  • Est. Priority Date: 12/02/2008
  • Status: Active Application
First Claim
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1. one kind is used for the synthetic method that comprises the nucleic acid of chirality X-phosphonic acid ester part, comprise the molecule that will comprise achiral H-phosphonic acid ester part and comprise 5 '"'"'-the nucleosides reaction of OH part to be to form the intermediate of condensation;

  • And the intermediate of condensation is converted into the nucleic acid that contains chirality X-phosphonic acid ester part.

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