Method for preparing felodipine

Method for preparing felodipine

  • CN 102,285,911 A
  • Filed: 07/12/2011
  • Published: 12/21/2011
  • Est. Priority Date: 07/12/2011
  • Status: Active Application
First Claim
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1. preparation method of felodipine, it is characterized in that:

  • with 2,3-dichlorobenzaldehyde and methyl acetoacetate are starting raw material, obtain 2 through Knoevenagel reaction condensation, 3-dichlorin benzylidene methyl acetoacetate, 2, the amino ethyl crotonate of 3-dichlorin benzylidene methyl acetoacetate and 3-obtains felodipine through Michael reaction cyclization.

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