Sodium alginate cross-linking Moxifloxacin sustained-release micro-spheres, Preparation Method And The Use and the blood-vessels target suppository containing described microsphere

Sodium alginate cross-linking Moxifloxacin sustained-release micro-spheres, Preparation Method And The Use and the blood-vessels target suppository containing described microsphere

  • CN 102,309,458 B
  • Filed: 07/09/2010
  • Issued: 02/03/2016
  • Est. Priority Date: 07/09/2010
  • Status: Active Grant
First Claim
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1. prepare a method for the Moxifloxacin sustained-release micro-spheres of sodium alginate cross-linking, it is characterized in that comprising the steps,be that 0.5 ~ 15% ratio is dissolved by sodium alginate normal saline or water for injection in quality percent by volume, obtain sodium alginate soln, that is, carrier solution;

  • 2) human albumin or bovine serum albumin water for injection are dissolved in quality percent by volume 0.1 ~ 10% ratio, obtain albumin solution, that is, adsorbent;

    3) by Moxifloxacin step

         2) adsorbent prepared grinding stirring and dissolving adsorbing, obtain Moxifloxacin solution, that is, drug solution, wherein the consumption of Moxifloxacin and adsorbent is 1.6 ~ 4% by quality percent by volume;

    4) divalent metal calcium salt or barium salt are mixed with the aqueous solution of quality percent by volume 1 ~ 15% concentration, obtain consolidation liquid;

    5) add dehydrated alcohol and water for injection by gained consolidation liquid, consolidation liquid;

    dehydrated alcohol;

    the volume ratio of water for injection is;

    2;

    1;

    2, the consolidation liquid of dehydrated alcohol must be contained;

    6) get gelatin or hyaluronic acid water for injection dissolves, obtain gelatin or the hyaluronic acid solution of quality percent by volume 0.1-10%, that is, strengthen solution;

    7) drug solution and carrier solution are merged in proportion, their volume ratio is;

    1;

    1 ~ 30, and magnetic agitation is even, must prepare solution;

    8) prepared by above-mentioned gained solution by high-pressure electrostatic bull microsphere generating means, spray droplets, is scattered in consolidation liquid, to be precipitated completely after remove supernatant, must containing the microsphere of the sodium alginate cross-linking of Moxifloxacin or micro gel bead;

    9) above-mentioned obtained microsphere or micro gel bead are put into reinforcement solution, stir, abandoning supernatant, must be with medicine microsphere or micro gel bead, that is, the Moxifloxacin sustained-release micro-spheres of sodium alginate cross-linking.

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