A disintegrating tablet

A disintegrating tablet

  • CN 102,316,874 B
  • Filed: 12/17/2009
  • Issued: 05/03/2017
  • Est. Priority Date: 12/17/2008
  • Status: Active Grant
First Claim
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1. a kind of disintegrating tablet, the disintegrating tablet is included:

  • At 25 DEG C, under 75% relative humidity, equilibrium moisture content is the medicine of 10-20%;

    Relative to the disintegrating tablet gross mass, antierythrite is 60-84% mass;

    Relative to the disintegrating tablet gross mass, mannitol is 1-20% mass;

    WithRelative to the disintegrating tablet gross mass, hydroxypropyl cellulose is 0.8-2% mass, and the hydroxypropyl cellulose is 25DEG C, under 75% relative humidity, equilibrium moisture content is 5-20%, when at 37 DEG C being the aqueous solution form of 20% mass, viscosityFor 100-2000cps;

    Wherein, the disintegrating tablet is comprising amount is for the medicine of the disintegrating tablet total amount 15-50% mass and has 10-40% porosity,The disintegrating tablet is mixed in the medicine, the antierythrite and the mannitol by (1);

    And (2) are with describedThe surface of each component included in the mixture obtained in non-aqueous solution wetting (1) of hydroxypropyl cellulose, is then dried instituteObtain thing and make,Concentration of the hydroxypropyl cellulose in the non-aqueous solution is 5-20%, and the solvent of the non-aqueous solution is firstAlcohol, ethanol.

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