Intranasal desmopressin administration

Intranasal desmopressin administration

  • CN 102,355,888 A
  • Filed: 12/21/2009
  • Published: 02/15/2012
  • Est. Priority Date: 12/22/2008
  • Status: Active Application
First Claim
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1. the safety distribution device is used for inducing antidiuretic activity the member of patient colony, and the member who reduces said colony simultaneously can develop into the risk of hyponatremia, and said allotter comprises:

  • Storage, said storage have wherein been placed the compositions of the membrane permeation reinforcing agent of the Desmopressin preparaton that contains the amount that is enough to constitute repeatedly drug dose and nose, and said compositions is characterised in that the Desmopressin bioavailability is higher than 5%;

    Outlet, said outlet is communicated with said storage;

    Manual steerable pump, said pump be used for said compositions with the Sprayable of dosing from said storage continuous dispensing through said outlet, and it is surperficial to arrive patient'"'"'s intranasal,Each spraying dosage is limited within 0.5ng Desmopressin/kg of patient body weight to the scope of 75ng Desmopressin/kg of patient body weight, so that in the member of said patient colony, realize being lower than the target C of 18pg/ml blood Max, The successive spraying dosage of each of equal volume passes the maximum haemoconcentration (C that sending of intranasal mucosa is enough in said patient, set up Desmopressin through transport of drug Max), the maximum haemoconcentration of said Desmopressin have with through being designed to realize same target C MaxThe C that produced of Desmopressin subcutaneous dosage MaxThe identical coefficient of variation of the coefficient of variation.

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