Trivalent, bispecific antibodies

Trivalent, bispecific antibodies

  • CN 102,369,214 A
  • Filed: 04/01/2010
  • Published: 03/07/2012
  • Est. Priority Date: 04/07/2009
  • Status: Active Application
First Claim
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1. trivalent, bi-specific antibody, said antibody comprises:

  • A) full length antibody, said full length antibody specificity are incorporated into first antigen and are made up of two heavy chain of antibody and two light chain of antibody;

    B) polypeptide, said polypeptide is made up of following;

    Ba) heavy chain of antibody variable domains (VH);

    OrBb) heavy chain of antibody variable domains (VH) and antibody constant domain 1 (CH1),The N-end of the VH structural domain of wherein said polypeptide is blended in one C-end of two heavy chains of said full length antibody through the peptide linker;

    C) polypeptide, said polypeptide is made up of following;

    Ca) light chain of antibody variable domains (VL), orCb) light chain of antibody variable domains (VL) and light chain of antibody constant domain (CL),The N-of the VL structural domain of wherein said polypeptide end is blended in another C-end of two heavy chains of said full length antibody through the peptide linker;

    And wherein at b) in polypeptide heavy chain of antibody variable domains (VH) and at c) in the light chain of antibody variable domains (VL) of polypeptide form specificity together and be incorporated into the second antigenic antigen binding site.

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