Supersaturated solution that gemcitabine hydrochloride is stable and preparation method thereof

Supersaturated solution that gemcitabine hydrochloride is stable and preparation method thereof

  • CN 102,406,603 B
  • Filed: 06/12/2006
  • Issued: 12/16/2015
  • Est. Priority Date: 06/12/2006
  • Status: Active Grant
First Claim
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1. gemcitabine hydrochloride supersaturated solution, first quantitative gemcitabine hydrochloride is added in solvent, it is characterized in that under the condition of pH5 ~ 8, quantitative gemcitabine hydrochloride is made to be dissolved in solvent completely by heating, obtain the gemcitabine hydrochloride supersaturated solution that concentration is 20 ~ 40g/L, described concentration is in gemcitabine;

  • Described heating-up temperature is 30 ~ 90 DEG C;

    Described solvent is the isotonic aqueous solution of water or biocompatibility;

    By degerming for above-mentioned gemcitabine hydrochloride supersaturated solution filtered while hot, press the direct fill of individual packaging dosage before cooling to final seal of vessel.

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