Prevention or treatment cachexia, weakness, fatigue and/or fever IL-6 antagonist

Prevention or treatment cachexia, weakness, fatigue and/or fever IL-6 antagonist

  • CN 102,438,653 B
  • Filed: 11/24/2009
  • Issued: 04/23/2019
  • Est. Priority Date: 11/25/2008
  • Status: Active Grant
First Claim
Patent Images

1. a kind of anti-IL-6 antibodies or antibody fragment and another reagent have IL-6 phase for preventing or treating diagnosis in preparationClose the purposes in the drug of cachexia in the patient of illness, weakness, fatigue and/or fever, wherein the anti-IL-6 antibodies orThe light chain of antibody fragment includes the CDR of SEQ ID NO:

  • 4,5 and 6 and the heavy chain of the anti-IL-6 antibodies or antibody fragment includesThe CDR of SEQ ID NO;

    7,8 or 120 and 9, another described reagent are selected from;

    5-HT3 receptor antagonist, ajwain, cholinolyticIt can medicine, antithistamine, Benzodiazepines, Cannabinoids, dexamethasone, Dopamine D2 receptor, Yi meter Te Er, ginger, beautySub- alkali, muscimol, nk1 receptor antagonist, peppermint, general Lu Bofu, nandrolone, reaction stops, the excitement of lenalidomide, ghrelinAgent, flesh chalone antagonist, selective androgen receptor modulators, selective estrogen receptor modulators, angiotensin AII are short of moneyAnti-agent, beta 2-adrenergic receptor agonists, beta 3 adrenoreceptor agonists, Proteolysis inducing factor, leukaemia suppressionThe factor and any combination thereof processed.

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