The preparation of the agonist anti-EDAR monoclonal antibody separated

The preparation of the agonist anti-EDAR monoclonal antibody separated

  • CN 102,448,991 B
  • Filed: 03/30/2010
  • Issued: 09/14/2016
  • Est. Priority Date: 03/30/2009
  • Status: Active Grant
First Claim
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1. the agonist anti-EDAR monoclonal antibody separated, it comprises:

  • A () comprises the heavy chain of the aminoacid sequence of SEQ ID NO;

    246, wherein, variable region of heavy chain CDR1 comprises SEQ ID NO;

    1, variable region of heavy chain CDR2 comprise SEQ ID NO;

    2, and variable region of heavy chain CDR3 comprises SEQ ID NO;

    3;

    And comprise SEQThe light chain of the aminoacid sequence of ID NO;

    183, wherein, variable region of light chain CDR1 comprises SEQ ID NO;

    4, variable region of light chain CDR2Comprise SEQ ID NO;

    5, and variable region of light chain CDR3 comprises SEQ ID NO;

    6;

    OrB () comprises the heavy chain of the aminoacid sequence of SEQ ID NO;

    248, wherein, variable region of heavy chain CDR1 comprises SEQ ID NO;

    13, variable region of heavy chain CDR2 comprise SEQ ID NO;

    14, and variable region of heavy chain CDR3 comprises SEQ ID NO;

    15;

    And compriseThe light chain of the aminoacid sequence of SEQ ID NO;

    185, wherein, variable region of light chain CDR1 comprises SEQ ID NO;

    16, light chain variableDistrict CDR2 comprises SEQ ID NO;

    17, and variable region of light chain CDR3 comprises SEQ ID NO;

    18,Wherein, the agonist anti-EDAR monoclonal antibody of the separation described in (a) and (b) is IgG1.

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