Bispecific immunocytokine dock-and-lock (DNL) complexes and therapeutic use thereof

Bispecific immunocytokine dock-and-lock (DNL) complexes and therapeutic use thereof

  • CN 102,481,348 A
  • Filed: 08/27/2010
  • Published: 05/30/2012
  • Est. Priority Date: 08/31/2009
  • Status: Active Application
First Claim
Patent Images

1. a DNL who comprises 3 kinds of different effect things part (stop and lock) construct;

  • Wherein said effector partly be connected to two DDD (dimerization with stop domain) part from PKA (PKA) with one from the proteic AD of AKAP (anchoring structure territory) part, and wherein said two DDD partly form dimer and partly combine the construct with formation DNL with AD.

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