The conditioning agent and its application method of 5 HT acceptors

The conditioning agent and its application method of 5 HT acceptors

  • CN 102,482,292 B
  • Filed: 04/22/2010
  • Issued: 07/18/2017
  • Est. Priority Date: 04/23/2009
  • Status: Active Grant
First Claim
Patent Images

1. compound or its medicinal acceptable salt, wherein compound are selected from:

  • 1,2,3,4,4a, 5- hexahydropyrazine simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    (4aS) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    The chloro- 1,2,3,4,4a of 10-, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    The bromo- 1,2,3,4,4a of 10-, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    10- phenyl -1,2,3,4,4a, 5- hexahydropyrazine simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    10- [(E) -2- phenyl vinyls] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    10- (3- chlorphenyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- (2- chlorphenyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- [(E) -2- (3- fluorophenyls) vinyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepineCycloheptatriene -6 (7H) -one;

    10- methyl isophthalic acids, 2,3,4,4a, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -10- nitriles;

    10- methoxyl groups -1,2,3,4,4a, 5- hexahydropyrazine simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    The bromo- 1,2,3,4,4a of 9-, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    9- (4- chlorphenyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -Ketone;

    The chloro- 1,2,3,4,4a of 9,10- bis-, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    7- methyl isophthalic acids, 2,3,4,4a, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    3- ethyls -1,2,3,4,4a, 5- hexahydropyrazine simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    The chloro- 1,2,3,4,4a of 3- benzyls -10-, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -Ketone;

    10- [(E) -2- (3- chlorphenyls) vinyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepineCycloheptatriene -6 (7H) -one;

    10- [(E) -2- (4- fluorophenyls) vinyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepineCycloheptatriene -6 (7H) -one;

    10- [(E) -2- (4- chlorphenyls) vinyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepineCycloheptatriene -6 (7H) -one;

    10- [(E) -2- (2,4 difluorobenzene base) vinyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzo twoAzepine cycloheptatriene -6 (7H) -one;

    10- (2- phenethyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    The bromo- 1,2,3,4,4a of 11-, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    10- (trifluoromethyl) -1,2,3,4,4a, 5- hexahydropyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    The fluoro- 1,2,3,4,4a of 8-, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    The fluoro- 1,2,3,4,4a of 11-, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    The fluoro- 1,2,3,4,4a of 9-, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    The fluoro- 1,2,3,4,4a of 10-, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    (4aS) -10- methyl isophthalic acids, 2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    The chloro- 1,2,3,4,4a of (4aS) -9,10- two, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    3- methyl isophthalic acids, 2,3,4,4a, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    3,3a, 4,5,6,7- hexahydro naphtho- [1,2-b] pyrazine simultaneously (1H) -one of [1,2-d] [1,4] diazacyclo heptantriene -2;

    8- methyl isophthalic acids, 2,3,4,4a, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    The chloro- 1,2,3,4,4a of (4aS) -10-, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -Ketone;

    (4aS) -10- (2- phenethyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    (4aS) -10- methoxyl groups -1,2,3,4,4a, 5- hexahydropyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- ethyoxyls -1,2,3,4,4a, 5- hexahydropyrazine simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    9- methyl isophthalic acids, 2,3,4,4a, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -10- formic acidEthyl ester;

    The chloro- 1,2,3,4,4a of 9-, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    10- cyclopropyl -1,2,3,4,4a, 5- hexahydropyrazine simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    11- methyl isophthalic acids, 2,3,4,4a, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    The chloro- 1,2,3,4,4a of (4aS) -9-, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -Ketone;

    10- (1- benzyl -1H- pyrazoles -4- bases) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine * heterocycleHeptantriene -6 (7H) -one;

    10- (2- naphthyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -Ketone;

    10- (4- methoxyphenyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- (biphenyl -3- bases) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- (1- methyl isophthalic acid H- pyrazoles -4- bases) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine * heterocycleHeptantriene -6 (7H) -one;

    10- (3- fluorophenyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- (quinoline -3- bases) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- (2- methoxyphenyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- (biphenyl -2- bases) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- (3- methoxyphenyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- (1- benzothiophene -3- bases) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    10- (1- naphthyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -Ketone;

    10- (1H- indoles -4- bases) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- (3- furyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- (2- fluorophenyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- (pyridine -2- bases) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- (3- thienyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- [3- (1H- pyrazol-1-yls) phenyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine * heterocycleHeptantriene -6 (7H) -one;

    10- (4- fluorophenyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- (1- benzothiophene -2- bases) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    N- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -9- bases)Benzsulfamide;

    Chloro- 7- ethyls -1,2,3,4,4a, the 5- hexahydropyrazines of 9- simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -Ketone;

    The chloro- 7- ethyls -3- methyl isophthalic acids of 9-, 2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -one;

    The fluoro- 3- methyl isophthalic acids of 8-, 2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -Ketone;

    The chloro- 7- methyl isophthalic acids of 9-, 2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -Ketone;

    The fluoro- 1,2,3,4,4a of (4aR) -8-, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -Ketone;

    The chloro- 3- methyl isophthalic acids of (4aS) -10-, 2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -one;

    The fluoro- 1,2,3,4,4a of (4aS) -8-, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -Ketone;

    The fluoro- 1,2,3,4,4a of (4aS) -11-, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -Ketone;

    The fluoro- 1,2,3,4,4a of (4aR) -11-, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -Ketone;

    The fluoro- 3- methyl isophthalic acids of (4aS) -8-, 2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- (3- aminomethyl phenyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- [3- (trifluoromethyl) phenyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    10- (3- ethylphenyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- (3- isopropyl phenyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- [3- (trifluoromethoxy) phenyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptylTriolefin -6 (7H) -one;

    10- (3- isopropyl phenyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    10- [3- (benzyloxy) phenyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    10- (3- isobutoxy phenyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    N- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -9- bases)Biphenyl -2- sulfonamide;

    2- methyl-N- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyls threeAlkene -9- bases) benzsulfamide;

    4- methyl-N- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyls threeAlkene -9- bases) benzsulfamide;

    3- methyl-N- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyls threeAlkene -9- bases) benzsulfamide;

    The chloro- N- of 3- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -9- yls) benzsulfamide;

    The chloro- N- of 4- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -9- yls) benzsulfamide;

    The fluoro- N- of 2- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -9- yls) benzsulfamide;

    The fluoro- N- of 3- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -9- yls) benzsulfamide;

    The fluoro- N- of 4- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -9- yls) benzsulfamide;

    2- methoxyl groups-N- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptylsTriolefin -9- bases) benzsulfamide;

    3- methoxyl groups-N- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptylsTriolefin -9- bases) benzsulfamide;

    4- methoxyl groups-N- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptylsTriolefin -9- bases) benzsulfamide;

    N- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -9- bases)Thiophene -2- sulfonamide;

    The chloro- 1,2,3,4,4a of 8-, 5- hexahydropyrazines simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6;

    10- (phenoxymethyl) -1,2,3,4,4a, 5- hexahydropyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    9- (phenyl sulfonyl) -1,2,3,4,4a, 5- hexahydropyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- [(2- fluorophenoxies) methyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    10- [(3- fluorophenoxies) methyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    10- [(4- fluorophenoxies) methyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    (4aS) -10- (2- fluorophenyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    (4aS) -10- (3- isopropyl phenyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine * heterocycleHeptantriene -6 (7H) -one;

    (4aS) -10- [2- (2- fluorophenyls) ethyoxyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine *Heterocycle heptantriene -6 (7H) -one;

    The chloro- N- of 2,6- bis- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptylsTriolefin -9- bases) benzsulfamide;

    N- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -9-Base) -3- (trifluoromethoxy) benzsulfamide;

    4- cyano group-N- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyls threeAlkene -9- bases) benzsulfamide;

    3- cyano group-N- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyls threeAlkene -9- bases) benzsulfamide;

    The fluoro- N- of 2,6- bis- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptylsTriolefin -9- bases) benzsulfamide;

    N- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -9- bases)Naphthalene -1- sulfonamide;

    2,5- dimethyl-N -s (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine * heterocycleHeptantriene -9- bases) benzsulfamide;

    N- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -9-Base) -2- (trifluoromethyl) benzsulfamide;

    The chloro- N- of 5- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -9- yls) thiophene -2- sulfonamide;

    N- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -9- bases)Naphthalene -2- sulfonamide;

    3,5- dimethyl-N -s (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine * heterocycleHeptantriene -9- bases) benzsulfamide;

    N- (6- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -9-Base) -2- (trifluoromethoxy) benzsulfamide;

    (4aS) -10- (difluoro-methoxy) -1,2,3,4,4a, 5- hexahydropyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    10- [(E) -2- (2- fluorophenyls) vinyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepineCycloheptatriene -6 (7H) -one;

    10- { (E) -2- [2- (trifluoromethyl) phenyl] vinyl } -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzeneAnd diazacyclo heptantriene -6 (7H) -one;

    10- [(E) -2- (3,5- difluorophenyls) vinyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzo twoAzepine cycloheptatriene -6 (7H) -one;

    10- [2- (2- fluorophenyls) ethyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    10- [2- (3- fluorophenyls) ethyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    10- { 2- [2- (trifluoromethyl) phenyl] ethyl } -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine *Heterocycle heptantriene -6 (7H) -one;

    10- [2- (3,5- difluorophenyls) ethyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine * heterocycleHeptantriene -6 (7H) -one;

    The chloro- 1,2,3,4,4a of (4aS) -8-, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -Ketone;

    10- (benzyloxy) -1,2,3,4,4a, 5- hexahydropyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -Ketone;

    7- methyl isophthalic acids 0- (2- phenylethyls) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptylTriolefin -6 (7H) -one;

    10- [2- (3- fluorophenyls) ethyoxyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptylTriolefin -6 (7H) -one;

    10- [(1R) -1- phenyl ethoxies] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptylTriolefin -6 (7H) -one;

    10- [(1S) -1- phenyl ethoxies] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptylTriolefin -6 (7H) -one;

    10- [(2- luorobenzyls) epoxide] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    10- [(3- luorobenzyls) epoxide] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptyl threeAlkene -6 (7H) -one;

    10- { [2- (trifluoromethyl) benzyl] epoxide } -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepineCycloheptatriene -6 (7H) -one;

    10- (2- phenyl ethoxies) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    10- { [(2R) -1- phenyl propyl- 2- yls] epoxide } -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine *Heterocycle heptantriene -6 (7H) -one;

    10- { [(2S) -1- phenyl propyl- 2- yls] epoxide } -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine *Heterocycle heptantriene -6 (7H) -one;

    10- [(1R) -1- (2- fluorophenyls) ethyoxyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine *Heterocycle heptantriene -6 (7H) -one;

    10- [(1S) -1- (2- fluorophenyls) ethyoxyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine *Heterocycle heptantriene -6 (7H) -one;

    (4aS) -10- { [(2S) -1- phenyl propyl- 2- yls] epoxide } -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzeneAnd diazacyclo heptantriene -6 (7H) -one;

    (4aS) -10- [2- (3- fluorophenyls) ethyoxyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine *Heterocycle heptantriene -6 (7H) -one;

    (4aS) -10- { [(2R) -1- phenyl propyl- 2- yls] epoxide } -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzeneAnd diazacyclo heptantriene -6 (7H) -one;

    (4aR) -10- { [(2R) -1- phenyl propyl- 2- yls] epoxide } -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzeneAnd diazacyclo heptantriene -6 (7H) -one;

    (4aR) -10- { [(2S) -1- phenyl propyl- 2- yls] epoxide } -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzeneAnd diazacyclo heptantriene -6 (7H) -one;

    (4aS) -10- (cyclo propyl methoxy) -1,2,3,4,4a, 5- hexahydropyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptylTriolefin -6 (7H) -one;

    (4aS) -10- [2- (pyridine -2- bases) ethyoxyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzo twoAzepine cycloheptatriene -6 (7H) -one;

    (4aS) -10- [2- (2- chlorphenyls) ethyoxyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine *Heterocycle heptantriene -6 (7H) -one;

    (4aS) -10- { 2- [3- (trifluoromethyl) phenyl] ethyoxyl } -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5]Benzodiazepine cycloheptatriene -6 (7H) -one;

    (4aS) -10- sec- butoxy -1,2,3,4,4a, 5- hexahydropyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -one;

    (4aS) -10- [2- (3- chlorphenyls) ethyoxyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine *Heterocycle heptantriene -6 (7H) -one;

    (4aS) -10- [2- (3- aminomethyl phenyls) ethyoxyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzo twoAzepine cycloheptatriene -6 (7H) -one;

    (4aS) -10- (1- phenyl-propoxies) -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptylTriolefin -6 (7H) -one;

    (4aS) -10- [(1R) -1- (2,5- difluorophenyls) ethyoxyl] -1,2,3,4,4a, 5- hexahydropyrazines simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6 (7H) -one;

    (4aS) -10- ethyoxyls -1,2,3,4,4a, 5- hexahydropyrazine simultaneously [1,2-a] [1,5] benzodiazepine cycloheptatriene -6(7H) -one;

    N- (7- oxos -1,2,3,4,4a, 5,6,7- octahydro pyrazine simultaneously [1,2-a] [1,4] benzodiazepine cycloheptatriene -9-Base) -3- (trifluoromethyl) benzsulfamide;

    With10- benzyls -1,2,3,4,4a, 5- hexahydropyrazine simultaneously (7H) -one of [1,2-a] [1,5] benzodiazepine cycloheptatriene -6.

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