Detecting Multinucleotide Repeats

Detecting Multinucleotide Repeats

  • CN 102,482,718 A
  • Filed: 07/12/2010
  • Published: 05/30/2012
  • Est. Priority Date: 07/10/2009
  • Status: Active Application
First Claim
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1. the method for the length of polynucleotide repeat region in the mensuration target nucleic acid comprises:

  • Amplification comprises that the target nucleic acid of polynucleotide repeat region is to produce the target nucleic acid of amplification;

    Target nucleic acid with first label and the said amplification of second label;

    It is proportional that said first label does not rely on polynucleotide multiple quantity and said second label and polynucleotide multiple quantity, and wherein said first label and second label are incorporated the target nucleic acid of said amplification independently of one another into during said amplification or after the amplification;

    The target nucleic acid of said amplification is bonded to the specific capture probe of the target nucleic acid of said amplification;

    Said first label that detection is associated with said capture probe is to produce first signal;

    Said second label that detection is associated with said capture probe is to produce second signal;

    AndMeasure the ratio of said first signal and said second signal, wherein said ratio is indicated the length of polynucleotide repeat region described in the said target nucleic acid.

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