Pharmaceutical compositions comprising bisphosphonate derivatives and high-dose cholecalciferol

Pharmaceutical compositions comprising bisphosphonate derivatives and high-dose cholecalciferol

  • CN 102,497,867 B
  • Filed: 06/17/2010
  • Issued: 04/29/2015
  • Est. Priority Date: 09/18/2009
  • Status: Active Grant
First Claim
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1. , for preventing or treat the pharmaceutical composition monthly used once of osteoporosis, it comprises:

  • The a granule containing cholecalciferol that () is obtained by adsorbent solution on microcrystalline Cellulose, described solution is by being equivalent to 24 by (i), 000-50, the cholecalciferol of the amount of 000IU, (ii) one or more are selected from the first stabilizing agent of tocopherol acetas, butylated hydroxytoluene and Butylated hydroxyanisole, and (iii) binding agent is dissolved in ethanol or ethanol water and prepares;

    B () is as the mannitol of the second stabilizing agent;

    And(c) risedronic acid or its salt or ibandronic acid or its salt.

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