The whole-cell vaccines of selective splitting

The whole-cell vaccines of selective splitting

  • CN 102,648,003 B
  • Filed: 10/12/2010
  • Issued: 01/13/2016
  • Est. Priority Date: 10/09/2009
  • Status: Active Grant
First Claim
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1. an immunogenic composition, described immunogenic composition comprises:

  • The part of the induction Multiple immunizations power of (i) streptococcus pneumoniae, described part is at least immiscible solvent, high volatile volatile reagent by using (a) or becomes a kind of solvent in the reagent of inactive forms or (b) sonicated after decomposing, by being prepared by soluble fraction and cellular portions by the full cell bacterial preparation selective splitting of streptococcus pneumoniae;

    And(ii)Al(OH) 3

    Wherein, described soluble fraction and described cellular portions are not removed from described full cell bacterial preparation;

    Further, the immunne response of described soluble fraction induction of antibodies mediation, the immunne response of described cellular portions induction IL-17A mediation.

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