Tamper resistant oral pharmaceutical dosage forms comprising an opioid analgesic

Tamper resistant oral pharmaceutical dosage forms comprising an opioid analgesic

  • CN 102,688,213 A
  • Filed: 08/24/2007
  • Published: 09/26/2012
  • Est. Priority Date: 08/25/2006
  • Status: Active Application
First Claim
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1. one kind comprises the Peroral solid dosage form prolongation release pharmaceutical dosage form that prolongs the release matrix preparation, and said prolongation release matrix preparation comprises the compositions that contains following composition:

  • (1) approximate molecular weight based on rheology measurement is at least 1,000,000 at least a PEO;

    And(2) oxycodone hydrochloride;

    WhereinSaid compositions in the said dosage form comprises the 10mg oxycodone hydrochloride and at least about the PEO of 85wt%, perhapsSaid compositions in the said dosage form comprises 15mg or 20mg oxycodone hydrochloride and at least about the PEO of 80wt%, perhapsSaid compositions in the said dosage form comprises the 40mg oxycodone hydrochloride and at least about the PEO of 65wt%, perhapsSaid compositions in the said dosage form comprises 60mg or 80mg oxycodone hydrochloride and at least about the PEO of 60wt%.

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