With the high molecular nanometer particles injection type compositionss containing rapamycin of water solubility and preparation method thereof for being lifted, and for anti-cancer composition associated with actinotherapy

With the high molecular nanometer particles injection type compositionss containing rapamycin of water solubility and preparation method thereof for being lifted, and for anti-cancer composition associated with actinotherapy

  • CN 102,740,834 B
  • Filed: 12/29/2010
  • Issued: 04/05/2017
  • Est. Priority Date: 12/30/2009
  • Status: Active Grant
First Claim
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1. the intravenous form compositionss of the high molecular nanometer particles containing rapamycin are being prepared for being joined with radiation therapyWith the purposes in the medicine for the treatment of mammal pulmonary carcinoma, it is characterised in that the note of the high molecular nanometer particles containing rapamycinPenetrate dosage form composition to include:

  • I) the A-B types being made up of the hydrophilic block (A) for methoxy poly (ethylene glycol) and the hydrophobic block (B) for polylactic acid are doubleBlock copolymer;

    Ii) the alkali metal salt of the polylactic acid of end at least containing a carboxyl or derivatives thereof;

    AndIii) as the rapamycin of active component;

    AndIv) the metal ion of divalent or trivalent,Wherein, the rapamycin is encapsulated in the alkali metal of the A-B types diblock copolymer and polylactic acid or derivatives thereofIn the micelle formed by salt, and after the intravenous form compositionss are reconstructed, the concentration of the rapamycin 0.1~

    25mg/mL。

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