human artificial chromosome vector

human artificial chromosome vector

  • CN 102,741,404 B
  • Filed: 11/17/2010
  • Issued: 03/08/2017
  • Est. Priority Date: 11/17/2009
  • Status: Active Grant
First Claim
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1. a kind of human artificial chromosome vector, it comprises:

  • A the gene of () encoding human antibodies heavy chain, the gene of wherein said encoding human antibodies'"'"' heavy chain at least encodes IgG(γ

    ) heavy chain, human IgA (α

    ) heavy chain or IgG and IgA heavy chain,The gene of (b) encoding human antibodies light chain, andC the gene of () encoding chimera IgM CH, wherein in human artificial chromosome vector, coding mankind'"'"'s IgM heavy chain is permanentThe DNA of the IgM CH that a part of DNA determining area is encoded ungulate replaces, so that:

    (i) encode mankind'"'"'s IgM weight chain constant area gene in CH1 domain, CH2 domain, CH3 domain, CH4 domain,The DNA of TM1 domain and TM2 domain is encoded the CH1 structure in the IgM weight chain constant area gene of ungulate respectivelyDomain, CH2 domain, CH3 domain, the DNA of CH4 domain, TM1 domain and TM2 domain replace;

    Or(ii) the CH2 domain in coding mankind'"'"'s IgM weight chain constant area gene, CH3 domain, CH4 domain, TM1 domainIt is encoded CH2 domain in the IgM weight chain constant area gene of ungulate, CH3 structure with the DNA of TM2 domain respectivelyDomain, the DNA of CH4 domain, TM1 domain and TM2 domain replace.

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