A kind of purification dihydropyridine calcium channel blocker the method preparing its nanometer

A kind of purification dihydropyridine calcium channel blocker the method preparing its nanometer

  • CN 102,746,217 B
  • Filed: 04/18/2011
  • Issued: 12/14/2016
  • Est. Priority Date: N/A
  • Status: Active Grant
First Claim
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1. one kind by ultrasonic crystallization technique to dihydropyridine calcium channel ion retardation agent class medicine and pharmaceutically useful salt thereofThe method being purified and directly prepare its nanoparticle, the size of described nanoparticle is 20nm~

  • 2000nm;

    First pass throughChange temperature, change solvent polarity or the method adding poor solvent, form dihydropyridine calcium channel ion retardation agent class medicineThing and the saturated or supersaturated solution of pharmaceutically useful salt thereof, then by nanoparticle that ultrasonic acquisition crystal size size is suitable.

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