Optically pure diastereomers of 10-propargyl-10-deazaaminopterin and methods of using same

Optically pure diastereomers of 10-propargyl-10-deazaaminopterin and methods of using same

  • CN 102,753,175 A
  • Filed: 03/04/2010
  • Published: 10/24/2012
  • Est. Priority Date: 02/02/2010
  • Status: Active Application
First Claim
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1. chemical compound;

  • It comprises pure basically diastereomer or its salt of the assorted aminopterin of 10-propargyl-10-denitrification;

    Wherein said diastereomer be (2S)-2-[[4-[(1S)-1-[(2;

    4-diaminourea pteridine-6-yl) methyl] fourth-3-alkynyl] benzoyl] amino] 1,3-propanedicarboxylic acid or (2S)-2-[[4-[(1R)-and 1-[(2,4-diaminourea pteridine-6-yl) methyl] fourth-3-alkynyl] benzoyl] amino] 1,3-propanedicarboxylic acid.

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