Scattered branched-chain fatty acids and biological production thereof

Scattered branched-chain fatty acids and biological production thereof

  • CN 102,791,870 A
  • Filed: 01/12/2011
  • Published: 11/21/2012
  • Est. Priority Date: 01/12/2010
  • Status: Active Application
First Claim
Patent Images

1. method;

  • Said method is used to produce the branched chain fatty acid that on one or more even carbon, comprises methyl;

    Said method is included in culturing cell under the condition of production of the expression that allows a kind of or more kinds of polynucleotide and branched chain fatty acid, and said cell comprises following polynucleotide;

    (aa) polynucleotide external or that express excessively;

    Said polynucleotide comprise the nucleic acid encoding sequence;

    Said polypeptide catalysis propionyl CoA changes into methylmalonyl CoA;

    And/or (bb) external or cross the polynucleotide of expressing, said polynucleotide comprise the nucleic acid encoding sequence, and said polypeptide catalysis succinyl CoA changes into methylmalonyl CoA;

    The more branched chain fatty acid of other similar cells produce of wherein said cell said a kind of or more kinds of polynucleotide than not comprising, said branched chain fatty acid comprises methyl on one or more even carbon.

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