Single-chain insulin

Single-chain insulin

  • CN 102,816,228 A
  • Filed: 12/03/2004
  • Published: 12/12/2012
  • Est. Priority Date: 12/03/2003
  • Status: Active Application
First Claim
Patent Images

1. have biological insulin activity and comprise the perhaps single-chain insulin of its analogue or verivate of the insulin human B that connects by connection peptides and A chain;

  • Connection peptides wherein has 5-11 amino-acid residue and does not contain two adjacent alkaline amino acid residues, and if the single-chain insulin molecule not by the acidylate chemically modified then wherein single-chain insulin be the insulin human to about at least 20% of the affinity of insulin human'"'"'s acceptor to the affinity of insulin human'"'"'s acceptor.

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